Irving Phil, Troxler Laurent, Hetru Charles
Institut de Biologie Moléculaire et Cellulaire du CNRS. 15, Strasbourg, France.
C R Biol. 2004 Jun;327(6):557-70. doi: 10.1016/j.crvi.2004.03.007.
In recent years, the innate immune system has emerged from the shadow of adaptive immune responses as a major area of research in its own right. One of the most significant model systems that has been used to investigate this phenomenon has been the fruit fly, Drosophila melanogaster. Exploration of the differential immune response presented by Drosophila led to the discovery of important signalling events and transduction pathways, which were thereafter shown to be specific for the type of infecting pathogen. These factors and pathways were subsequently found to have homologues in many other organisms, including those with adaptive immune responses. In light of the present status of studies in innate immunity, this review describes the current state of understanding of the Drosophila immune response.
近年来，固有免疫系统已从适应性免疫反应的阴影中脱颖而出，成为其自身重要的研究领域。果蝇（Drosophila melanogaster）是用于研究这一现象的最重要模型系统之一。对果蝇呈现的差异性免疫反应的探索，导致了重要信号事件和转导途径的发现，这些事件和途径随后被证明对感染病原体的类型具有特异性。这些因子和途径随后在许多其他生物中被发现具有同源物，包括那些具有适应性免疫反应的生物。鉴于固有免疫研究的现状，本综述描述了对果蝇免疫反应的当前理解状态。
