ABT-492对厌氧菌的体外活性。

In vitro activity of ABT-492 against anaerobic bacteria.

作者信息

Sillerström E, Wahlund E, Nord C E

机构信息

Division of Clinical Bacteriology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.

出版信息

J Chemother. 2004 Jun;16(3):227-9. doi: 10.1179/joc.2004.16.3.227.

DOI:10.1179/joc.2004.16.3.227

PMID:15330316

Abstract

The purpose of the study was to determine the in vitro activity of ABT-492 compared with that of other antimicrobial agents against anaerobic bacteria. The activity of ABT-492 was investigated against 369 clinical isolates of anaerobic bacteria by the agar dilution method and was compared with that of moxifloxacin, piperacillin, cefoxitin, imipenem, clindamycin and metronidazole. ABT-492 and imipenem were the most active antimicrobial agents tested.

摘要

本研究的目的是确定ABT - 492与其他抗菌药物相比对厌氧菌的体外活性。采用琼脂稀释法研究了ABT - 492对369株临床分离厌氧菌的活性，并与莫西沙星、哌拉西林、头孢西丁、亚胺培南、克林霉素和甲硝唑进行了比较。ABT - 492和亚胺培南是测试中活性最强的抗菌药物。