新型喹诺酮BAY y 3118对厌氧菌的体外活性
In vitro activity of the new quinolone BAY y 3118 against anaerobic bacteria.
作者信息
Nord C E, Lindmark A, Persson I
机构信息
Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Sweden.
出版信息
Eur J Clin Microbiol Infect Dis. 1993 Aug;12(8):640-2. doi: 10.1007/BF01973648.
The in vitro activity of BAY y 3118 against anaerobic cocci, Propionibacterium acnes, Clostridium perfringens, Clostridium difficile, Bacteroides fragilis, other Bacteroides spp. and fusobacteria was determined by an agar dilution method. This activity was compared with that of ciprofloxacin, ofloxacin, piperacillin, cefoxitin, imipenem, clindamycin and metronidazole. BAY y 3118, imipenem, clindamycin and metronidazole were the most active agents tested. The in vitro activity of BAY y 3118 against anaerobic bacteria was superior to that of ciprofloxacin and ofloxacin.
采用琼脂稀释法测定了BAY y 3118对厌氧球菌、痤疮丙酸杆菌、产气荚膜梭菌、艰难梭菌、脆弱拟杆菌、其他拟杆菌属以及梭杆菌属的体外活性。将该活性与环丙沙星、氧氟沙星、哌拉西林、头孢西丁、亚胺培南、克林霉素和甲硝唑的活性进行了比较。BAY y 3118、亚胺培南、克林霉素和甲硝唑是所测试的活性最强的药物。BAY y 3118对厌氧菌的体外活性优于环丙沙星和氧氟沙星。
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