Rossi R, Puccioni M, Mavilia L, Campolmi P, Mori M, Cappuccini A, Reali E F, Cappugi P
Department of Dermatological Sciences, Dermatological Physiotherapy, University of Florence, Florence, Italy.
J Chemother. 2004 Jun;16(3):306-9. doi: 10.1179/joc.2004.16.3.306.
The ocular tissues can be the site of a number of malignant tumors in adults. Approximately 5% to 10% of all skin tumors occur in the eyelid. Incidence studies indicate that basal cell carcinoma is the most frequent malignant eyelid tumor (90%) followed by squamous cell carcinoma (9%). A 55-year-old man presented a squamous cell carcinoma (SCC) of 8 mm diameter, localized in the middle third of the lower eyelid, 3 mm under the eyelid margin on the eyelids. The histopathologic examination of a biopsy specimen showed the typical features of squamous cell carcinoma. Photodynamic therapy (PDT) with topical 5-aminolevulic acid (ALA) after Frost suture was employed. Very good results were obtained with rapid healing, without invasiveness, and without anesthesia. There was no evidence of scar formation and no signs of recurrence at 6 months follow-up. Many therapeutic methods have been suggested for squamous cell carcinoma of the eyelid. We consider photodynamic treatment of eyelid skin malignancies to be of great interest and it may represent an interesting future perspective for their management especially when surgical intervention cannot be tolerated by the patient.
眼部组织可能是成人多种恶性肿瘤的发病部位。所有皮肤肿瘤中约有5%至10%发生在眼睑。发病率研究表明，基底细胞癌是最常见的恶性眼睑肿瘤（90%），其次是鳞状细胞癌（9%）。一名55岁男性患者，下眼睑中三分之一处、睑缘下方3毫米处出现直径8毫米的鳞状细胞癌。活检标本的组织病理学检查显示出鳞状细胞癌的典型特征。采用了Frost缝线后外用5-氨基酮戊酸（ALA）的光动力疗法（PDT）。取得了非常好的效果，愈合迅速，无侵袭性，无需麻醉。随访6个月时，没有瘢痕形成的迹象，也没有复发的迹象。对于眼睑鳞状细胞癌，已经提出了许多治疗方法。我们认为眼睑皮肤恶性肿瘤的光动力治疗非常有意义，对于其治疗可能代表着一个有趣的未来前景，尤其是当患者无法耐受手术干预时。
