Storelli Maria M, Storelli Arianna, Marcotrigiano Giuseppe O
Pharmacological-Biological Department, Chemistry and Biochemistry Section, Veterinary Medicine Faculty, University of Bari, Strada Prov le per Casamassima Km 3, 70010 Valenzano (Ba), Italy.
J Food Prot. 2004 Aug;67(8):1787-91. doi: 10.4315/0362-028x-67.8.1787.
Levels of polychlorinated biphenyls (PCBs), hexachlorobenzene, hexachlorocyclohexane isomers (alpha, beta, gamma), and chlorinated pesticides (DDTs) in cod-liver oil used as a dietary supplement were determined. Total PCB and DDT concentrations varied from 25 to 201 ng g(-1) lipid weight basis and from 25 to 133 ng g(-1) lipid weight basis, respectively. Hexachlorobenzene contributed very little to the overall contaminant burden of dietary supplement oils, whereas hexachlorocyclohexane isomers were below the instrumental detection limits in all samples. The daily intake of PCBs and DDTs derived by the consumption of cod-liver oil at manufacturer-recommended doses varied from 0.004 to 2.01 microg/day and from 0.004 to 1.24 microg/day, respectively. Relative to some dioxin-like PCB congeners (mono-ortho PCB 105, 118, and 156; non-ortho PCB 77, 126, and 169), the intakes calculated varied from less than 0.001 to 0.74 pg of toxic equivalency values (TEQ) per kg of body weight per day. These values, although below the range of 1 to 4 pg of TEQ per kg of body weight per day set by the World Health Organization, emphasize the need for strict and continuous monitoring of fish oil contamination to reduce, as much as possible, the risks to human health.
对用作膳食补充剂的鳕鱼肝油中多氯联苯（PCBs）、六氯苯、六氯环己烷异构体（α、β、γ）和氯化农药（滴滴涕）的含量进行了测定。总多氯联苯和滴滴涕浓度分别以脂质重量计为25至201纳克/克和25至133纳克/克。六氯苯对膳食补充剂油的总体污染物负担贡献很小，而六氯环己烷异构体在所有样品中均低于仪器检测限。按照制造商推荐剂量食用鳕鱼肝油所摄入的多氯联苯和滴滴涕，每日摄入量分别为0.004至2.01微克/天和0.004至1.24微克/天。相对于某些类二噁英多氯联苯同系物（单邻位多氯联苯105、118和156；非邻位多氯联苯77、126和169），计算得出的摄入量为每天每千克体重低于0.001至0.74皮克毒性当量值（TEQ）。这些数值虽然低于世界卫生组织设定的每天每千克体重1至4皮克毒性当量值范围，但强调了需要对鱼油污染进行严格持续监测，以尽可能降低对人类健康的风险。
