Hotta N, Kakuta H, Fukasawa H, Koh N, Sakakibara F, Komori H, Sakamoto N
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Diabetes. 1992 May;41(5):587-91. doi: 10.2337/diab.41.5.587.
Niceritrol, a drug with peripheral tissue vasodilatory and serum lipid-lowering activity, was administered for 2 mo to rats with streptozocin-induced diabetes. Physiological and biochemical studies were subsequently conducted on rat nerve tissue. A markedly lower value of approximately 47% in sciatic nerve blood flow (SNBF) was detected in an untreated diabetic (DC) group than in a nondiabetic control group (CC). A significant delay in caudal motor nerve conduction velocity (MNCV) and significantly higher glucose, sorbitol, and fructose values were observed in the sciatic nerve and serum lipids. In contrast, a niceritrol-treated diabetic (DN) group had significantly higher SNBF, MNCV, and sciatic nerve myo-inositol values and lower serum triglyceride levels than group DC. No differences between these two groups were noted in glucose, sorbitol, and fructose levels in the sciatic nerve, or in cholesterol and glucose in serum. These findings suggest that niceritrol has a clear inhibitory effect on the development of delayed MNCV in the diabetic rat, which may be due to reduced nerve blood flow and/or decreased nerve myo-inositol levels.
尼可占替诺是一种具有外周组织血管舒张和降血脂活性的药物，将其给予链脲佐菌素诱导的糖尿病大鼠2个月。随后对大鼠神经组织进行了生理和生化研究。在未治疗的糖尿病（DC）组中，坐骨神经血流量（SNBF）比非糖尿病对照组（CC）显著降低约47%。在坐骨神经中观察到尾侧运动神经传导速度（MNCV）显著延迟，葡萄糖、山梨醇和果糖值显著升高，血清脂质也有变化。相比之下，尼可占替诺治疗的糖尿病（DN）组的SNBF、MNCV和坐骨神经肌醇值显著高于DC组，血清甘油三酯水平低于DC组。两组在坐骨神经中的葡萄糖、山梨醇和果糖水平，或血清中的胆固醇和葡萄糖方面没有差异。这些发现表明，尼可占替诺对糖尿病大鼠延迟的MNCV发展具有明显的抑制作用，这可能是由于神经血流量减少和/或神经肌醇水平降低所致。
