治疗晚期冈比亚型昏睡病2年后10天美拉胂醇疗程的疗效
Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness.
作者信息
Schmid C, Nkunku S, Merolle A, Vounatsou P, Burri C
机构信息
Swiss Tropical Institute, 4002 Basel, Switzerland.
出版信息
Lancet. 2004;364(9436):789-90. doi: 10.1016/S0140-6736(04)16940-7.
In 2000, we reported that a new short treatment schedule of melarsoprol was not worse than the longer and demanding standard treatment for late-stage human African trypanosomiasis. This alternative schedule was assessed in an open, randomised clinical equivalence trial of 500 patients in Angola. 24 h after treatment, all patients were parasite free. Of 442 patients, 12 (3%) had relapsed after 1 year, of whom seven (3%) had had standard treatment and five (2%) the alternative treatment. After 2 years, 23 (5%) relapsing patients were reported, 11 (5%) in the standard treatment group and 12 (6%) in the new group. The results at the 2-year follow-up support and strengthen our previous findings.
2000年，我们报告称，对于晚期人类非洲锥虫病，一种新的短疗程美拉胂醇治疗方案并不比更长且要求更高的标准治疗方案效果差。在安哥拉对500名患者进行的一项开放、随机临床等效性试验中对这种替代方案进行了评估。治疗24小时后，所有患者均无寄生虫。在442名患者中，12名（3%）在1年后复发，其中7名（3%）接受了标准治疗，5名（2%）接受了替代治疗。2年后，报告有23名（5%）患者复发，标准治疗组有11名（5%），新治疗组有12名（6%）。2年随访结果支持并强化了我们之前的研究结果。
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