Xu Jun, Wang Qi-xin, Fan Chun-lei, Jiang Dong, Li Ruo-bing, Cong Xu, Fei Ran, Chen Hong-song, Wei Lai, Wang Yu
Hepatology Institute, People's Hospital, Beijing University, Beijing 100044, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003 Dec;17(4):327-9.
To understand HBV serotypes and genotypes epidemiology in a northern city and a southern city in China.
Using polymerase chain reaction (PCR) and direct sequencing of HBV DNA PCR products, the serotypes and genotypes of HBV in 530 from HBsAg positive samples. The enrolled patients were from Harbin, a northern city and Lianjiang, a southern city in China.
Comparison of the serotypes and genotypes of HBV between Harbin and Lianjiang showed that adrq+ was the most predominant hepatitis B virus serotype in both Harbin and Lianjiang (87.2% and 73.5%,respectively), adw2 was the next (12.0% and 25.7%, respectively); genotype C was the most frequent in Harbin and Lianjiang (87.8% and 73.2%, respectively), and genotype B was the next (12.2% and 26.1%, respectively) only 1 patient was infected by genotype D, and 1 patient was found to be co-infected by genotype B and C in Lianjiang.
The results suggest that the percentage of HBV serotypes and genotypes between Harbin and Lianjiang was significantly different (P less than 0.001), but the main HBV serotype and genotype of the two cities were similar.
了解中国北方某市和南方某市的乙肝病毒（HBV）血清型和基因型流行病学情况。
采用聚合酶链反应（PCR）及对HBV DNA PCR产物进行直接测序，检测来自中国北方城市哈尔滨和南方城市连江的530份HBsAg阳性样本中HBV的血清型和基因型。
哈尔滨和连江HBV血清型和基因型的比较显示，adrq+是哈尔滨和连江最主要的乙肝病毒血清型（分别为87.2%和73.5%），其次是adw2（分别为12.0%和25.7%）；基因型C在哈尔滨和连江最为常见（分别为87.8%和73.2%），其次是基因型B（分别为12.2%和26.1%），连江仅有1例患者感染基因型D，1例患者被发现同时感染基因型B和C。
结果表明，哈尔滨和连江之间HBV血清型和基因型的百分比存在显著差异（P<0.001），但两市主要的HBV血清型和基因型相似。
