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[中国重庆地区流行的B基因型/adrw2血清型或C基因型/adrq+血清型乙型肝炎病毒PreS/S区共有序列的建立]

[Establishment of consensus sequence of PreS/S of hepatitis B virus with genotype B/serotype adw2 or genotype C/serotype adrq+ prevailing in Chongqing of China].

作者信息

Xu Hong-Mei, Ren Hong, Qing Yu-Ling, Peng Ming-Li, Ling Ning

机构信息

The Institute of Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Oct;24(10):913-6.

PMID:14575607
Abstract

OBJECTIVE

To develop consensus sequence of HBV PreS/S with different subtype in Chongqing of China.

METHODS

The gene of PreS/S of HBV in 18 AsC was sequenced. The genotype and serotype of HBV were determined. The main HBV strain prevailing in Chongqing was identified to establish its consensus sequence.

RESULTS

It was found that 9 strains were genotype B/serotype adw2, 6 were genotype C/serotype adrq+ and 3 were genotype B/serotype ayw1. The consensus sequence of PreS/S of HBV with genotype B/serotype adw2 and genotype C/serotype adrq+ were established. There were 6 nucleotide variants which causing 4 amino acids change between consensus sequence of PreS/S with genotype B/serotype adw2 in Chongqing and in Southeast of China (homology showed 99.5% and 99.0% respectively). There were 13 different sites that caused 4 amino acids change between consensus sequence of PreS/S with genotype C/serotype adrq+ in Chongqing and in Northeast and South of China (homology showed 98.9% and 99.0% respectively). Comparing the two consensus sequence of PreS/S gene of different subtype HBV in Chongqing, there was 95 variants which caused 40 amino acids variants (the homology was 92.1% and 90.0% respectively).

CONCLUSION

The consensus sequence of PreS/S of hepatitis B virus with genotype B/serotype adw2 and genotype C/serotype adrq+ prevailing in Chongqing was established.

摘要

目的

构建中国重庆地区不同亚型乙肝病毒（HBV）PreS/S基因的共有序列。

方法

对18例慢性乙肝患者（AsC）的HBV PreS/S基因进行测序，确定HBV的基因型和血清型，找出重庆地区主要流行的HBV毒株并构建其共有序列。

结果

发现9株为B基因型/adw2血清型，6株为C基因型/adrq+血清型，3株为B基因型/ayw1血清型。成功构建了B基因型/adw2血清型和C基因型/adrq+血清型HBV的PreS/S基因共有序列。重庆地区B基因型/adw2血清型HBV的PreS/S基因共有序列与中国东南部地区相比，有6个核苷酸变异，导致4个氨基酸改变（同源性分别为99.5%和99.0%）。重庆地区C基因型/adrq+血清型HBV的PreS/S基因共有序列与中国东北和南部地区相比，有13个不同位点，导致4个氨基酸改变（同源性分别为98.9%和99.0%）。比较重庆地区不同亚型HBV的PreS/S基因的两个共有序列，有95个变异，导致40个氨基酸变异（同源性分别为92.1%和90.0%）。

结论

成功构建了重庆地区流行的B基因型/adw2血清型和C基因型/adrq+血清型乙肝病毒PreS/S基因的共有序列。

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