Cassidenti D L, Pike M C, Vijod A G, Stanczyk F Z, Lobo R A
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Am J Obstet Gynecol. 1992 May;166(5):1444-8. doi: 10.1016/0002-9378(92)91617-j.
Hypoestrogenism in postmenopausal smokers has been suggested as the mechanism for the observed decreased risk of endometrial cancer and increased risk of osteoporosis. We have prospectively studied a well-matched group of smokers and nonsmokers and have evaluated their estrogen levels and compared them with existing data from the literature. We conclude that increased adrenal activity resulting in increased androgens, mainly androstenedione, is seen in postmenopausal smokers but that estrogen levels are not decreased. We hypothesize that in nonusers, unlike in users of estrogen, smoking is not associated with changes in estrogen levels and that other mechanisms must be responsible for the epidemiologic observations seen.
绝经后吸烟者体内雌激素水平降低被认为是观察到的子宫内膜癌风险降低和骨质疏松症风险增加的机制。我们前瞻性地研究了一组匹配良好的吸烟者和非吸烟者，评估了他们的雌激素水平，并将其与文献中的现有数据进行了比较。我们得出结论，绝经后吸烟者存在肾上腺活动增加，导致雄激素（主要是雄烯二酮）增加，但雌激素水平并未降低。我们假设，与雌激素使用者不同，在非使用者中，吸烟与雌激素水平变化无关，其他机制必定是造成所观察到的流行病学现象的原因。
