Tessler M, Dascal A, Gioseffini S, Miller M, Mendelson J
Department of Anaesthesia and Medicine, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.
Can J Anaesth. 1992 May;39(5 Pt 1):509-11. doi: 10.1007/BF03008718.
Propofol, 2,6 diisopropylphenol, in an emulsion formulation (Diprivan), has been associated with postsurgical infections caused by Staphylococcus aureus, Moraxella osloensis and Candida albicans. These organisms were individually inoculated into each of the following media: (1) the emulsion preparation of propofol, (2) Intralipid 10%, (3) pure 2,6 diisopropylphenol, and (4) trypticase soy broth (TSB). The organisms were incubated and subcultured hourly for eight hours at room temperature. Propofol supported the growth of all three organisms, but for S. aureus and M. osloenis, the growth rate was slower in propofol than in TSB (P less than 0.05). There was no difference between the growth rate of any organism in propofol than in Intralipid 10%. The authors conclude that propofol, in the emulsion formulation, supports bacterial growth and, therefore, must be prepared for administration in an aseptic manner. Also, by administering propofol soon after preparation, the risk of introduction of a significant inoculum to the patient will be reduced.
丙泊酚，即2,6 - 二异丙基苯酚，制成乳剂配方（得普利麻）后，与金黄色葡萄球菌、奥斯陆莫拉菌和白色念珠菌引起的术后感染有关。将这些微生物分别接种到以下每种培养基中：（1）丙泊酚乳剂制剂，（2）10%英脱利匹特，（3）纯2,6 - 二异丙基苯酚，以及（4）胰蛋白胨大豆肉汤（TSB）。将这些微生物在室温下培养8小时，每小时传代培养一次。丙泊酚支持所有三种微生物的生长，但对于金黄色葡萄球菌和奥斯陆莫拉菌，其在丙泊酚中的生长速度比在TSB中慢（P小于0.05）。任何微生物在丙泊酚中的生长速度与在10%英脱利匹特中的生长速度没有差异。作者得出结论，乳剂配方的丙泊酚支持细菌生长，因此，必须以无菌方式配制以供给药。此外，在配制后尽快给予丙泊酚，将降低向患者引入大量接种物的风险。
