Paradossi Gaio, Cavalieri Francesca, Chiessi Ester, Spagnoli Chiara, Cowman Mary K
Department of Chemical Sciences and Technologies and INFM section B, University of Rome Tor Vergata, Italy.
J Mater Sci Mater Med. 2003 Aug;14(8):687-91. doi: 10.1023/a:1024907615244.
In this paper, we present some new case examples where the chemical versatility of poly (vinyl alcohol) (PVA) can be used for potential biomedical applications. PVA, the polymeric material used for designing new nanostructured devices, is water soluble, biocompatible and has excellent physical properties. We point out the possibility of obtaining wall-to-wall chemical hydrogels as well as microgels without diminishing the biocompatibility available in the starting PVA material. Injectability is another important factor to take into account in controlled drug delivery for gene therapy. In this respect, in this paper, established and more innovative methods are prospected in order to obtain particles with dimensions suitable for these applications.
在本文中，我们展示了一些新的案例，其中聚乙烯醇（PVA）的化学多功能性可用于潜在的生物医学应用。PVA是用于设计新型纳米结构装置的聚合材料，它可溶于水、具有生物相容性且具备优异的物理性能。我们指出了在不降低起始PVA材料生物相容性的情况下获得全化学水凝胶以及微凝胶的可能性。可注射性是基因治疗中控制药物递送需要考虑的另一个重要因素。在这方面，本文展望了成熟的和更具创新性的方法，以获得尺寸适合这些应用的颗粒。
