Komlev V S, Barinov S M
Institute for Physical Chemistry of Ceramics RAS, Ozernaya 48, Moscow, 119361, Russia.
J Mater Sci Mater Med. 2002 Mar;13(3):295-9. doi: 10.1023/a:1014015002331.
A route for the fabrication of porous hydroxyapatite ceramics having two populations of open pores is reported. The bodies are prepared by sintering the spherical gelatin/hydroxyapatite granules. As the result, ceramics containing intragranular small-size pores and intergranular large-size interconnecting pores are obtained. The pore size and content are dependent on the route. Ceramics can generally be applied as bone replacement materials where the interconnections in the intergranular pores are the pathway to conduct cells and vessels for the bone ingrowth, whereas the intragranular pores can be filled with a drug, e.g. to eliminate infections.
报道了一种制备具有两种开孔群体的多孔羟基磷灰石陶瓷的方法。通过烧结球形明胶/羟基磷灰石颗粒来制备坯体。结果得到了含有颗粒内小尺寸孔隙和颗粒间大尺寸相互连通孔隙的陶瓷。孔径和含量取决于制备方法。这种陶瓷通常可作为骨替代材料,其中颗粒间孔隙的连通性是引导细胞和血管长入骨内的通道,而颗粒内孔隙可填充药物,例如用于消除感染。