Reichelt K-L, Jensen D
Institute of Pediatric Research, University of Oslo, Oslo, Norway.
Acta Neurol Scand. 2004 Oct;110(4):239-41. doi: 10.1111/j.1600-0404.2004.00303.x.
Multiple changes in antibodies against various antigens are found in multiple sclerosis (MS).
We wanted to measure immunoglobulin A (IgA) antibodies to some common food antigens in MS and also IgG against gliadin and gluten.
The IgA antibodies were measured in serum against gluten, gliadin, lactoglobulin, lactalbumin, casein and ovalbumin in patients with MS and controls using ELISA technique. IgG was likewise measured for gluten and gliadin.
Highly significant increases compared with controls were found for IgA and IgG antibodies against gliadin and gluten. IgA antibodies against casein were significantly increased. Anti-endomycium and anti-transglutaminase antibodies were negative.
The data presented indicate that there may be a possible moderately increased uptake of some specific proteins from the gut in MS compared with controls.
在多发性硬化症（MS）中发现针对多种抗原的抗体存在多种变化。
我们想要检测MS患者体内针对一些常见食物抗原的免疫球蛋白A（IgA）抗体以及针对麦醇溶蛋白和麸质的IgG抗体。
采用酶联免疫吸附测定（ELISA）技术检测MS患者和对照组血清中针对麸质、麦醇溶蛋白、乳球蛋白、乳白蛋白、酪蛋白和卵白蛋白的IgA抗体。同样检测针对麸质和麦醇溶蛋白的IgG抗体。
与对照组相比，针对麦醇溶蛋白和麸质的IgA和IgG抗体显著升高。针对酪蛋白的IgA抗体显著增加。抗肌内膜抗体和抗转谷氨酰胺酶抗体均为阴性。
所呈现的数据表明，与对照组相比，MS患者可能从肠道中适度增加摄取某些特定蛋白质。
