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雷特综合征中的IgA抗体。

IgA antibodies in Rett syndrome.

作者信息

Reichelt K L, Skjeldal O

机构信息

Institute of Pediatric Research, The National Hospital, University of Oslo, N-0027 Oslo, Norway.

出版信息

Autism. 2006 Mar;10(2):189-97. doi: 10.1177/1362361306062024.

DOI:10.1177/1362361306062024
PMID:16613867
Abstract

The level of IgA antibodies to gluten and gliadin proteins found in grains and to casein found in milk, as well as the level of IgG to gluten and gliadin, have been examined in 23 girls with Rett syndrome and 53 controls. Highly statistically significant increases were found for the Rett population compared to the controls. The reason for this remains unknown, but because IgA antibodies reflect the uptake of proteins and/or epitopes of proteins from the gut, this may be indicative of increased protein uptake.

摘要

对23名患有雷特综合征的女孩和53名对照者检测了其血液中针对谷物中的麸质和麦醇溶蛋白以及牛奶中的酪蛋白的IgA抗体水平,以及针对麸质和麦醇溶蛋白的IgG水平。与对照组相比,雷特综合征患者组的这些抗体水平在统计学上有显著升高。其原因尚不清楚,但由于IgA抗体反映了肠道对蛋白质和/或蛋白质表位的摄取情况,这可能表明蛋白质摄取增加。

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