Haeryfar S M Mansour, Hoskin David W
Cellular Biology and Viral Immunology Sections, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
J Immunol. 2004 Sep 15;173(6):3581-8. doi: 10.4049/jimmunol.173.6.3581.
Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation. However, a physiological ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been identified. Thy-1 cross-linking, in the context of strong costimulatory signaling through CD28, results in an activating signal that can at least partially substitute for TCR signaling during mouse T cell activation. Remarkably, Thy-1 cross-linking also results in the potent costimulation of T cells activated through the TCR. This novel dual signaling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the absence of TCR triggering, as well as potentiating Ag-induced T cell responses.
Thy-1（CD90）是一种小的糖基磷脂酰肌醇（GPI）锚定蛋白，在小鼠胸腺细胞和外周T细胞表面特别丰富。通过特异性单克隆抗体（mAb）使Thy-1交联所引发的T细胞增殖和细胞因子合成表明Thy-1在小鼠T淋巴细胞活化中发挥作用。然而，尚未在淋巴组织中鉴定出小鼠Thy-1的生理配体或反受体。在通过CD28进行的强共刺激信号传导的背景下，Thy-1交联会产生一种激活信号，该信号在小鼠T细胞活化过程中至少可以部分替代TCR信号传导。值得注意的是，Thy-1交联还会导致通过TCR活化的T细胞得到有效的共刺激。这种新的双重信号传导能力表明，Thy-1在无TCR触发的情况下维持T细胞稳态以及增强抗原诱导的T细胞反应中可能发挥作用。
