Rashad A L, Toffler W L, Wolf N, Thornburg K, Kirk E P, Ellis G, Whitehead W E
Department of Pathology, Oregon Health Sciences University, School of Medicine, Portland 97201.
Am J Obstet Gynecol. 1992 Feb;166(2):620-4. doi: 10.1016/0002-9378(92)91687-6.
We measured the PO2, pH, and temperature in the vaginal canals of nine patients with symptomatic Trichomonas vaginitis and those of 10 healthy women. The patients included eight women with primary infections caused by metronidazole-susceptible strains and one refractory case that resulted from infection with a metronidazole-resistant Trichomonas vaginalis. The median vaginal PO2, pH, and temperature in the patient group were 1 mm Hg, 6, and 37.3 degrees C respectively; these medians were 1 mm Hg, less than or equal to 4.5, and 37.2 degrees C in the healthy group. These data show that vaginal environment is anaerobic or microaerophilic (it has reduced oxygen tension). Because the activity of metronidazole is reduced under aerobiosis, the vaginal environment should enhance the biologic activity of the drug.
我们测量了9例有症状的滴虫性阴道炎患者以及10名健康女性阴道内的氧分压（PO2）、pH值和温度。患者包括8例由甲硝唑敏感菌株引起的初次感染女性和1例因感染甲硝唑耐药阴道毛滴虫导致的难治性病例。患者组阴道PO2、pH值和温度的中位数分别为1毫米汞柱、6和37.3摄氏度；健康组的这些中位数分别为1毫米汞柱、小于或等于4.5以及37.2摄氏度。这些数据表明阴道环境为厌氧或微需氧环境（氧张力降低）。由于甲硝唑在有氧条件下活性降低，阴道环境应能增强该药物的生物活性。
