Yokoi Norihiko, Bron Anthony J, Tiffany John M, Maruyama Kunio, Komuro Aoi, Kinoshita Shigeru
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kaiji-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto 602-0841, Japan.
Arch Ophthalmol. 2004 Sep;122(9):1265-9. doi: 10.1001/archopht.122.9.1265.
To investigate the relationship between tear volume and tear meniscus curvature by means of the video meniscometer.
Eleven eyes of 11 patients with severe dry eye were studied (all female; mean +/- SD age, 66.2 +/- 7.7 years; 7 left eyes and 4 right eyes), each of whose puncta had been therapeutically occluded. Four instillations of balanced salt solution were given at intervals of 1 minute in each studied eye, with the concentration increasing in 5-microL steps from 5 to 20 microL. Before and after the instillation of balanced salt solution, tear meniscus changes were recorded by video meniscometer and radius of the meniscus was calculated from the printed images by means of the concave mirror formula.
The mean radius of the meniscus increased linearly with increased drop volume (r(2) = 0.65, P<.001), with mean +/- SD radius values of 0.24 +/- 0.08 mm at baseline and 0.48 +/- 0.13, 0.62 +/- 0.13, 0.84 +/- 0.26, and 1.00 +/- 0.32 mm after separate instillations of 5, 10, 15, and 20 microL of balanced salt solution, respectively. For each subject, a significantly different slope defining the relationship between instilled volume and meniscus radius was seen (0.016-0.063 mm/ microL; mean +/- SD, 0.039 +/- 0.015 mm/ microL), which was thought to depend on the difference in capacity of the fluid reservoir over the ocular surface.
This study confirmed that the volume of instilled eyedrops is linearly related to the resulting radius of the tear meniscus, suggesting that this radius is a useful measure in monitoring the tear volume. This is likely to have implications both for dry eye diagnosis and for confirming the efficacy of punctal occlusion in this condition.
通过视频泪液弯月面测量仪研究泪液量与泪液弯月面曲率之间的关系。
对11例重度干眼患者的11只眼进行研究（均为女性；平均年龄±标准差为66.2±7.7岁；左眼7只，右眼4只），所有患者的泪点均已进行治疗性封闭。每只研究眼每隔1分钟滴注4次平衡盐溶液，浓度从5微升以5微升的步长递增至20微升。在滴注平衡盐溶液前后，用视频泪液弯月面测量仪记录泪液弯月面的变化，并通过凹面镜公式从打印图像计算弯月面半径。
弯月面的平均半径随滴注量的增加呈线性增加（r² = 0.65，P<0.001），分别滴注5、10、15和20微升平衡盐溶液后，平均半径±标准差在基线时为0.24±0.08毫米，滴注后分别为0.48±0.13、0.62±0.13、0.84±0.26和1.00±0.32毫米。对于每个受试者，观察到定义滴注量与弯月面半径之间关系的斜率存在显著差异（0.016 - 0.063毫米/微升；平均±标准差为0.039±0.015毫米/微升），认为这取决于眼表上液体储存能力的差异。
本研究证实滴注眼药水的量与由此产生的泪液弯月面半径呈线性相关，表明该半径是监测泪液量的有用指标。这可能对干眼诊断以及确认在此情况下泪点封闭的疗效都有意义。
