Djoussé Luc, Schatzkin Arthur, Chibnik Lori B, D'Agostino Ralph B, Kreger Bernard E, Ellison R Curtis
Preventive Medicine and Epidemiology Section, Evans Department of Medicine, Boston University School of Medicine, Rm. B-612, 715 Albany St., Boston, MA 02118, USA.
J Natl Cancer Inst. 2004 Sep 15;96(18):1397-400. doi: 10.1093/jnci/djh263.
The association between alcohol consumption and bladder cancer is controversial. We used data from 10,125 participants in the Framingham Heart Study to assess the association between total and beverage-specific alcohol consumption and the risk of bladder cancer. For each case of bladder cancer, up to five control subjects were selected and matched on major confounders using a risk set method. We used conditional logistic regression to assess the risk of bladder cancer according to categories of alcohol consumption. During a mean follow-up of 27.3 +/- 10.1 years, there were 126 incident cases of bladder cancer. There was no statistically significant association between alcohol consumption and risk of bladder cancer (P(trend) =.3). In beverage-specific analyses, beer consumption was associated with a reduced risk of bladder cancer (P(trend) =.03), whereas wine (P(trend) =.7) and spirit (P(trend) =.2) consumption were not. Our data suggest that total and beverage-specific alcohol consumption are not associated with an increased risk of bladder cancer.
饮酒与膀胱癌之间的关联存在争议。我们使用了弗雷明汉心脏研究中10125名参与者的数据，以评估总酒精摄入量和特定饮料酒精摄入量与膀胱癌风险之间的关联。对于每一例膀胱癌病例，使用风险集方法选择多达五名对照受试者，并根据主要混杂因素进行匹配。我们使用条件逻辑回归根据酒精摄入量类别评估膀胱癌风险。在平均27.3±10.1年的随访期间，有126例膀胱癌新发病例。酒精摄入量与膀胱癌风险之间没有统计学上的显著关联（P趋势=.3）。在特定饮料分析中，饮用啤酒与膀胱癌风险降低相关（P趋势=.03），而饮用葡萄酒（P趋势=.7）和烈酒（P趋势=.2）则不然。我们的数据表明，总酒精摄入量和特定饮料酒精摄入量与膀胱癌风险增加无关。
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