Lin H C, Moller N A, Wolinsky M M, Kim B H, Doty J E, Meyer J H
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Gastroenterology. 1992 Mar;102(3):787-92. doi: 10.1016/0016-5085(92)90159-v.
The distal small intestine is an especially potent site for carbohydrate-triggered intestinal inhibition of gastric emptying of solids. Poorly digestible carbohydrates, such as lentils, may escape proximal absorption, travel over time to reach these inhibitory mechanisms, and slow the gastric emptying of a later meal. A slowing effect on gastric emptying may be associated with a lowering effect on postprandial glucose. The aims of this study were to determine (a) whether lentils (a poorly digestible carbohydrate) vs. bread (an easily digestible carbohydrate) eaten as a premeal (with equal amounts of carbohydrates) slow the gastric emptying of a second solid meal taken 4.0-4.5 hours later and (b) whether a slowing effect on the gastric emptying of the second meal is associated with a lower postprandial glucose response. We found that in 7 dogs and 10 humans, gastric emptying of the second meal was delayed after a lentil premeal compared with a bread premeal. However, there was no difference in the glucose response to the second meal under the two conditions.
远端小肠是碳水化合物引发肠道抑制固体食物胃排空的一个特别有效的部位。难消化的碳水化合物，如小扁豆，可能无法在近端被吸收，随着时间推移到达这些抑制机制，并减缓后续餐食的胃排空。胃排空减慢的效应可能与餐后血糖降低的效应相关。本研究的目的是确定：（a）作为餐前食物食用的小扁豆（一种难消化的碳水化合物）与面包（一种易消化的碳水化合物）（碳水化合物含量相等）是否会减缓4.0 - 4.5小时后摄入的第二顿固体餐食的胃排空；以及（b）第二餐胃排空的减慢效应是否与较低的餐后血糖反应相关。我们发现，在7只狗和10名人类受试者中，与面包餐前相比，小扁豆餐前会延迟第二餐的胃排空。然而，在这两种情况下，第二餐的血糖反应没有差异。
