Lin H C, Kim B H, Elashoff J D, Doty J E, Gu Y G, Meyer J H
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Gastroenterology. 1992 Mar;102(3):793-801. doi: 10.1016/0016-5085(92)90160-z.
Although glucose sensors regulating the gastric emptying of liquid meals are uniformly distributed throughout the canine small intestine, some data suggest that the distal small bowel more potently inhibits gastric emptying of solid foods. The aims of this study were to compare (a) the inhibition of gastric emptying by glucose sensors in the proximal intestine with the feedback from the distal intestine, (b) these effects on the gastric emptying of solids vs. liquids, and (c) the inhibitory effect of unhydrolyzed starch with glucose. In 7 dogs with chronic duodenal fistulas, the second, third, and fourth quarters of small bowel were perfused via chronically implanted transmural catheters. Gastric emptying of either solids or liquids was tracked by gamma camera while gastric output was diverted out the duodenal fistula and the small bowel perfused with test solutions of glucose (0.06-2.0 mol/L), 0.15 mol/L NaCl, or 8.5% soluble starch. It was found that (a) gastric emptying of solids but not liquids was approximately 3 times more potently inhibited by glucose in the fourth quarter vs. the first or second quarter of small bowel, and (b) only hydrolyzed starch inhibited gastric emptying of solids.
尽管调节流食胃排空的葡萄糖传感器均匀分布于犬的整个小肠，但一些数据表明，小肠远端对固体食物胃排空的抑制作用更强。本研究的目的是比较：（a）近端小肠中葡萄糖传感器对胃排空的抑制作用与远端小肠的反馈作用；（b）这些作用对固体食物和液体食物胃排空的影响；（c）未水解淀粉与葡萄糖的抑制作用。在7只患有慢性十二指肠瘘的犬中，通过长期植入的透壁导管对小肠的第二、第三和第四区段进行灌注。通过γ相机追踪固体或液体的胃排空情况，同时将胃内容物经十二指肠瘘引出，并向小肠灌注葡萄糖（0.06 - 2.0 mol/L）、0.15 mol/L氯化钠或8.5%可溶性淀粉的测试溶液。结果发现：（a）与小肠第一或第二区段相比，第四区段的葡萄糖对固体食物胃排空的抑制作用约为其三倍，而对液体食物胃排空无此作用；（b）只有水解淀粉能抑制固体食物的胃排空。
