Meyer J H, Hlinka M, Kao D, Lake R, MacLaughlin E, Graham L S, Elashoff J D
Department of Medicine, VAMC, Sepulveda, California, USA.
Dig Dis Sci. 1996 Sep;41(9):1691-9. doi: 10.1007/BF02088732.
Digestion of fat in pancreatic insufficiency (PI) is strongly affected by how rapidly fat enters the duodenum. We postulated that: (1) oil empties faster in PI than in normals and (2) in both, it empties in a load-dependent fashion. We used a gamma camera to test these ideas by comparing gastric emptying of iodine-123 iodinated oil in normal and pancreatic-insufficient subjects after 15 g of free oil were ingested in a small spaghetti meal and 60 g of oil were ingested in a large spaghetti meal and in a milk emulsion. Indium-113m marked gastric emptying of water in the milk. In both groups after all meals, oil emptied fastest initially, slowing later; and oil emptied three to four times faster when 60 g vs 15 g were ingested. There were no significant differences between the groups of subjects with respect to gastric emptying of the spaghetti meals, but the pancreatic-insufficient subjects emptied both oil and water faster from the milk emulsion than did the normal subjects. The slower emptying of oil in the normal subjects was associated with significantly more layering of oil to the top of the intragastric milk emulsion.
胰腺功能不全（PI）时脂肪的消化受到脂肪进入十二指肠速度的强烈影响。我们推测：（1）PI患者中油的排空速度比正常人快；（2）在这两种情况下，油的排空都呈负荷依赖性。我们使用γ相机，通过比较正常人和胰腺功能不全患者在摄入15克游离油的小份意大利面餐、60克油的大份意大利面餐以及牛奶乳剂后碘-123碘化油的胃排空情况，来检验这些想法。铟-113m标记了牛奶中水的胃排空情况。在两组患者的所有餐食后，油最初排空最快，随后减慢；摄入60克油时的油排空速度比摄入15克油时快三到四倍。两组受试者在意大利面餐的胃排空方面没有显著差异，但胰腺功能不全的受试者从牛奶乳剂中排空油和水的速度都比正常受试者快。正常受试者中油排空较慢与胃内牛奶乳剂顶部油的分层明显更多有关。
