Finch Caleb E, Crimmins Eileen M
Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA.
Science. 2004 Sep 17;305(5691):1736-9. doi: 10.1126/science.1092556.
Most explanations of the increase in life expectancy at older ages over history emphasize the importance of medical and public health factors of a particular historical period. We propose that the reduction in lifetime exposure to infectious diseases and other sources of inflammation--a cohort mechanism--has also made an important contribution to the historical decline in old-age mortality. Analysis of birth cohorts across the life-span since 1751 in Sweden reveals strong associations between early-age mortality and subsequent mortality in the same cohorts. We propose that a "cohort morbidity phenotype" represents inflammatory processes that persist from early age into adult life.
历史上大多数关于老年人口预期寿命增长的解释都强调特定历史时期医学和公共卫生因素的重要性。我们认为，一生中接触传染病和其他炎症源的减少——一种队列效应机制——也对历史上老年死亡率的下降做出了重要贡献。对瑞典自1751年以来整个寿命期出生队列的分析表明，同队列中早年死亡率与随后的死亡率之间存在紧密关联。我们提出，“队列发病表型”代表了从幼年持续到成年期的炎症过程。
