Kuiken Carla, Yusim Karina, Boykin Laura, Richardson Russell
HCV database, Los Alamos National Laboratory, Los Alamos, NM, USA.
Bioinformatics. 2005 Feb 1;21(3):379-84. doi: 10.1093/bioinformatics/bth485. Epub 2004 Sep 17.
The hepatitis C virus (HCV) is a significant threat to public health worldwide. The virus is highly variable and evolves rapidly, making it an elusive target for the immune system and for vaccine and drug design. At present, some 30 000 HCV sequences have been published. A central website that provides annotated sequences and analysis tools will be helpful to HCV scientists worldwide.
The HCV sequence database collects and annotates sequence data and provides them to the public via a website that contains a user-friendly search interface and a large number of sequence analysis tools, based on the model of the highly regarded Los Alamos HIV database. The HCV sequence database was officially launched in September 2003. Since then, its usage has steadily increased and is now at an average of approximately 280 visits per day from distinct IP addresses.
The HCV website can be accessed via http://hcv.lanl.gov and http://hcv-db.org.
丙型肝炎病毒（HCV）对全球公共卫生构成重大威胁。该病毒高度可变且进化迅速，这使其成为免疫系统以及疫苗和药物设计难以捉摸的目标。目前，已发表了约30000条HCV序列。一个提供注释序列和分析工具的中央网站将对全球的HCV科学家有所帮助。
HCV序列数据库收集并注释序列数据，并通过一个网站将其提供给公众，该网站基于备受推崇的洛斯阿拉莫斯HIV数据库的模式，包含用户友好的搜索界面和大量序列分析工具。HCV序列数据库于2003年9月正式推出。自那时以来，其使用量稳步增加，现在平均每天来自不同IP地址的访问量约为280次。
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