Kuiken Carla, Hraber Peter, Thurmond James, Yusim Karina
HCV database, Los Alamos National Laboratory, Los Alamos, NM, USA.
Nucleic Acids Res. 2008 Jan;36(Database issue):D512-6. doi: 10.1093/nar/gkm962. Epub 2007 Nov 19.
The hepatitis C virus (HCV) is a significant public health threat worldwide. The virus is highly variable and evolves rapidly, making it an elusive target for the immune system and for vaccine and drug design. Presently, approximately 50 000 HCV sequences have been published. A central website that provides annotated sequences and analysis tools will be helpful to HCV scientists worldwide. The HCV sequence database collects and annotates sequence data, and provides them to the public via a website that contains a user-friendly search interface and a large number of sequence analysis tools, following the model of the highly regarded and widely used Los Alamos HIV database. The HCV website can be accessed via http://hcv.lanl.gov and http://hcv-db.org.
丙型肝炎病毒(HCV)是全球重大的公共卫生威胁。该病毒具有高度变异性且进化迅速,这使其成为免疫系统以及疫苗和药物设计难以,难以攻克的目标。目前,已发表了约50000条HCV序列。一个提供带注释序列和分析工具的中央网站,将对全球的HCV科学家有所帮助。HCV序列数据库收集并注释序列数据,并按照备受推崇且广泛使用的洛斯阿拉莫斯HIV数据库的模式,通过一个包含用户友好搜索界面和大量序列分析工具的网站将这些数据提供给公众。可通过http://hcv.lanl.gov和http://hcv-db.org访问HCV网站。