Theoretical Biology and Biophysics, T-10, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Nucleic Acids Res. 2012 Jan;40(Database issue):D587-92. doi: 10.1093/nar/gkr898. Epub 2011 Nov 7.
Hemorrhagic fever viruses (HFVs) are a diverse set of over 80 viral species, found in 10 different genera comprising five different families: arena-, bunya-, flavi-, filo- and togaviridae. All these viruses are highly variable and evolve rapidly, making them elusive targets for the immune system and for vaccine and drug design. About 55,000 HFV sequences exist in the public domain today. A central website that provides annotated sequences and analysis tools will be helpful to HFV researchers worldwide. The HFV sequence database collects and stores sequence data and provides a user-friendly search interface and a large number of sequence analysis tools, following the model of the highly regarded and widely used Los Alamos HIV database [Kuiken, C., B. Korber, and R.W. Shafer, HIV sequence databases. AIDS Rev, 2003. 5: p. 52-61]. The database uses an algorithm that aligns each sequence to a species-wide reference sequence. The NCBI RefSeq database [Sayers et al. (2011) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res., 39, D38-D51.] is used for this; if a reference sequence is not available, a Blast search finds the best candidate. Using this method, sequences in each genus can be retrieved pre-aligned. The HFV website can be accessed via http://hfv.lanl.gov.
出血热病毒 (HFVs) 是一组多样化的超过 80 种病毒，存在于包含五个不同科的 10 个不同属中：沙粒病毒科、布尼亚病毒科、黄病毒科、丝状病毒科和披膜病毒科。所有这些病毒都具有高度的变异性和快速进化的能力，使得它们成为免疫系统、疫苗和药物设计的难以捉摸的目标。目前，公共领域中存在约 55,000 种 HFV 序列。一个提供注释序列和分析工具的中央网站将有助于全球的 HFV 研究人员。HFV 序列数据库收集和存储序列数据，并提供用户友好的搜索界面和大量的序列分析工具，遵循备受推崇和广泛使用的 Los Alamos HIV 数据库的模型[Kuiken, C., B. Korber, and R.W. Shafer, HIV sequence databases. AIDS Rev, 2003. 5: p. 52-61]。该数据库使用一种算法，将每个序列与全物种参考序列对齐。使用的数据库是 NCBI RefSeq 数据库[Sayers et al. (2011) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res., 39, D38-D51.]；如果没有参考序列，Blast 搜索会找到最佳候选序列。使用这种方法，可以预先对齐每个属中的序列。HFV 网站可以通过 http://hfv.lanl.gov 访问。
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