Tzung Tien-Yi, Wu Kuan-Hsing, Huang Mei-Lun
Department of Dermatology, Veterans General Hospital Kaohsiung, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan.
Photodermatol Photoimmunol Photomed. 2004 Oct;20(5):266-9. doi: 10.1111/j.1600-0781.2004.00109.x.
Blue light irradiation is known to be effective against acne. However, the profile of a good candidate is still unclear.
Thirty-one Taiwanese with symmetrical facial acne were irradiated with blue light on one side of the face selected randomly twice weekly for 4 consecutive weeks. The other half of the face was left untreated as control. Parameters, including scar type, pore size, and facial follicular porphyrin fluorescence intensity, were documented. The severity of acne was assessed before the treatment, after two, four, and eight sessions of treatment, and 1 month after the treatment was completed.
Compared with the non-irradiation side, eight sessions of blue light irradiation were effective in acne treatment (P<0.001). Gender (P=0.471), scar type (P-values of pitted, atrophic, and hypertrophic type were 0.688, 0.572, and 0.802, respectively), pore size (P=0.755), and pretreatment fluorescence intensity (P=0.656) could not be used as predictive factors of therapeutic effectiveness. Compared with pretreatment, nodulocystic lesions tended to worsen despite treatment. In addition, the therapeutic effectiveness was not related to the fluorescence intensity change (P=0.812).
Blue light irradiation is effective in acne treatment. Patients without nodulocystic lesions are better candidates for blue light irradiation.
已知蓝光照射对痤疮有效。然而，理想的治疗对象特征仍不明确。
31名面部痤疮对称的台湾患者，随机选择一侧面部每周照射蓝光两次，连续照射4周。另一侧面部不做处理作为对照。记录包括瘢痕类型、毛孔大小和面部毛囊卟啉荧光强度等参数。在治疗前、治疗2次、4次和8次后以及治疗结束后1个月评估痤疮的严重程度。
与未照射侧相比，8次蓝光照射对痤疮治疗有效（P<0.001）。性别（P=0.471）、瘢痕类型（凹陷性、萎缩性和肥厚性瘢痕的P值分别为0.688、0.572和0.802）、毛孔大小（P=0.755）和治疗前荧光强度（P=0.656）均不能作为治疗效果的预测因素。与治疗前相比，结节囊肿性损害尽管经过治疗仍有加重倾向。此外，治疗效果与荧光强度变化无关（P=0.812）。
蓝光照射对痤疮治疗有效。无结节囊肿性损害的患者更适合蓝光照射。
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