Sawai H, Lohrmann R, Orgel L E
J Mol Evol. 1975 Nov 4;6(3):165-84. doi: 10.1007/BF01732354.
When a solution containing gly-N-pa and imidazole is evaporated to dryness and then maintained at a temperature between 65 degrees C and 100 degrees C, high yields of AppA and obligoglycines are obtained. We believe that ImpA is formed first, and then activates the carboxyl group of glycine or gly-A-pA. If glycine, ATP or AppA, and imidazole are heated together in the solid state, ImpA is formed and ATP , or indirectly from imidazole and gly-N-pA. Next the carboxyl group or glycine is activated by the ImpA formed in situ. The subsequent reactions of activated glycine leads to the formation of oligoglycines and the 2' (3')-glycylester of pA. Under plausible prebiobic conditions, good yields of oligoglycines up to the octamer can be obtained from glycine, ATP and imidazole.
当含有甘氨酰 - N - 对氨基苯甲酰谷氨酸（gly - N - pA）和咪唑的溶液蒸发至干，然后保持在65摄氏度至100摄氏度之间的温度时，可获得高产率的AppA和寡聚甘氨酸。我们认为首先形成ImpA，然后激活甘氨酸或甘氨酰 - A - pA的羧基。如果甘氨酸、ATP或AppA以及咪唑在固态下一起加热，会形成ImpA，ATP则间接由咪唑和甘氨酰 - N - pA形成。接下来，原位形成的ImpA激活羧基或甘氨酸。活化甘氨酸的后续反应导致寡聚甘氨酸和对氨基苯甲酰谷氨酸的2'（3'） - 甘氨酰酯的形成。在合理的前生物条件下，从甘氨酸、ATP和咪唑可以获得高产率的直至八聚体的寡聚甘氨酸。
