Harvey Natasha L, Oliver Guillermo
Department of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38105, USA.
Curr Opin Genet Dev. 2004 Oct;14(5):499-505. doi: 10.1016/j.gde.2004.07.005.
The specification of cell fate is integral to embryonic development. Recent research has identified several molecules that are involved in the development of the embryonic vasculature. Their combined actions are required for the specification and development of the arteries, veins and lymphatic vessels; vascular networks that are vital for embryonic and adult survival, and whose malfunction causes major pathological disorders. Recent discoveries have impacted our understanding of the embryonic origins of arterial, venous and lymphatic endothelial cells and the signals that mediate their navigation into mature, functional circulatory systems.
细胞命运的特化是胚胎发育不可或缺的一部分。最近的研究已经确定了几种参与胚胎血管系统发育的分子。它们的联合作用对于动脉、静脉和淋巴管的特化与发育是必需的；这些血管网络对于胚胎和成年个体的生存至关重要，其功能失调会导致严重的病理紊乱。最近的发现影响了我们对动脉、静脉和淋巴管内皮细胞的胚胎起源以及介导它们进入成熟、功能性循环系统的信号的理解。
