Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA.
University of Illinois Cancer Center, Chicago, Illinois 60612, USA.
Cold Spring Harb Perspect Med. 2022 Nov 1;12(11):a041183. doi: 10.1101/cshperspect.a041183.
As vascular networks form, endothelial cells (ECs) undergo cell fate decisions that determine whether they become tip or stalk cells of the developing vascular plexus or mature into arterial, venous, or lymphatic endothelium. EC fate decisions are coordinated with neighboring cells to initiate sprouting, maintain endothelial barrier, or ensure appropriate specialization of vessels. We describe mechanisms that control EC fate at specific steps in these processes, with an emphasis on the role of the Notch signaling pathway. Specific EC fate determination steps that are highlighted are tip/stalk selection during sprouting angiogenesis, venous-arterial specification, arteriogenesis, lymphatic vessel specification, and lymphatic valve formation.
随着血管网络的形成，内皮细胞（ECs）经历细胞命运决定，决定它们成为发育中的血管丛的尖端或茎细胞，还是成熟为动脉、静脉或淋巴管内皮细胞。EC 命运决定与相邻细胞协调，以启动发芽、维持内皮屏障或确保血管的适当特化。我们描述了控制这些过程中特定步骤的 EC 命运的机制，重点介绍了 Notch 信号通路的作用。突出显示的特定 EC 命运决定步骤包括发芽血管生成期间的尖端/茎选择、静脉-动脉特化、动脉生成、淋巴管特化和淋巴管瓣形成。
