Takakusaki K, Saitoh K, Harada H, Kashiwayanagi M
Department of Physiology, Asahikawa Medical College, Midorigaoka-Higashi 2-1, Asahikawa 078-8510, Japan.
Neurosci Res. 2004 Oct;50(2):137-51. doi: 10.1016/j.neures.2004.06.015.
Here we review a role of a basal ganglia-brainstem (BG-BS) system throughout the mesopontine tegmentum in the control of various types of behavioral expression. First the basal ganglia-brainstem system may contribute to an automatic control of movements, such as rhythmic limb movements and adjustment of postural muscle tone during locomotion, which occurs in conjunction with voluntary control processes. Second, the basal ganglia-brainstem system can be involved in the regulation of awake-sleep states. We further propose the possibility that the basal ganglia-brainstem system is responsible for the integration of volitionally-guided and emotionally-triggered expression of motor behaviors. It can be proposed that dysfunction of the basal ganglia-brainstem system together with that of cortico-basal ganglia loop underlies the pathogenesis of behavioral disturbances expressed in basal ganglia dysfunction.
在此，我们回顾了贯穿中脑桥脑被盖的基底神经节-脑干（BG-BS）系统在控制各种行为表达中的作用。首先，基底神经节-脑干系统可能有助于对运动进行自动控制，例如有节奏的肢体运动以及在运动过程中对姿势肌肉张力的调节，这些运动与自主控制过程同时发生。其次，基底神经节-脑干系统可能参与觉醒-睡眠状态的调节。我们进一步提出，基底神经节-脑干系统负责整合意志引导和情感触发的运动行为表达。可以认为，基底神经节-脑干系统功能障碍以及皮质-基底神经节环路功能障碍是基底神经节功能障碍中行为紊乱发病机制的基础。
