针对硕大利什曼原虫感染的Th1依赖性免疫的要求。
Requirements for Th1-dependent immunity against infection with Leishmania major.
作者信息
von Stebut Esther, Udey Mark C
机构信息
Department of Dermatology, Johannes Gutenberg-University, Langenbeckstrasse 1, D-55101 Mainz, Germany.
出版信息
Microbes Infect. 2004 Oct;6(12):1102-9. doi: 10.1016/j.micinf.2004.05.024.
Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Th1-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted.
针对皮肤利什曼病的保护性免疫依赖于Th1/Tc1免疫反应的诱导，从而有效清除寄生虫。在这篇综述中，我们将讨论导致保护的机制，特别关注利什曼原虫主要感染的树突状细胞（DC）在诱导Th1依赖性免疫中的作用。文中强调了利什曼原虫易感小鼠与抗性小鼠来源的DC之间的鼠株依赖性差异。
Zotero 插件