共轭亚油酸对成年去卵巢大鼠钙吸收、骨代谢及骨成分的影响。
The effect of conjugated linoleic acid on calcium absorption and bone metabolism and composition in adult ovariectomised rats.
作者信息
Kelly O, Cashman K D
机构信息
Department of Food & Nutritional Sciences, University College, Western Road, Cork, Ireland.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2004 Nov;71(5):295-301. doi: 10.1016/j.plefa.2004.04.003.
The effect of conjugated linoleic acid (CLA) on postmenopausal bone metabolism has not been investigated. Therefore, forty-three adult ovariectomised (OVX) rats (8-9 rats per group) were fed either a control diet containing 40 g/kg soyabean oil (SBO diet) or the SBO diet with 0 (control OVX), 2.5, 5 or 10 g/kg of CLA (replacing soybean oil) for 9 weeks. A group of sham-operated (SH) rats were fed the SBO diet. OVX rats had significantly (P<0.05) lower femoral bone mineral density and macromineral concentration, and intestinal Ca absorption compared to SH rats. CLA supplementation had no effect on these parameters. Ex vivo PGE(2) biosynthesis by bone and urinary Pyr and Dpyr (markers of bone resorption) were significantly higher (P<0.001) in control OVX rats compared with SH rats, and were significantly (P<0.001) lowered by CLA supplementation with 5 and 10, but not 2.5 g/kg diet in OVX rats. In conclusion, CLA supplementation appeared to reduce the rate of bone resorption in adult OVX rats.
共轭亚油酸（CLA）对绝经后骨代谢的影响尚未得到研究。因此，将43只成年去卵巢（OVX）大鼠（每组8 - 9只）分为两组，分别喂食含40 g/kg大豆油的对照饮食（SBO饮食），以及含0（对照OVX）、2.5、5或10 g/kg CLA（替代大豆油）的SBO饮食，持续9周。一组假手术（SH）大鼠喂食SBO饮食。与SH大鼠相比，OVX大鼠的股骨骨矿物质密度、常量矿物质浓度及肠道钙吸收显著降低（P<0.05）。补充CLA对这些参数没有影响。与SH大鼠相比，对照OVX大鼠骨组织离体前列腺素E2（PGE(2)）生物合成及尿吡啶啉（Pyr）和脱氧吡啶啉（Dpyr）（骨吸收标志物）显著升高（P<0.001），而在OVX大鼠中，补充5和10 g/kg（而非2.5 g/kg）饮食的CLA可使其显著降低（P<0.001）。总之，补充CLA似乎可降低成年OVX大鼠的骨吸收速率。
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