McCARTY M
J Exp Med. 1949 Dec;90(6):543-53. doi: 10.1084/jem.90.6.543.
Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Certain patients develop inhibitory antibody to streptococcal desoxyribonuclease following streptococcal infections, occasionally in very high titer, although the proportion of patients showing an antibody response appears to be lower than in the case of streptokinase and streptolysin O. The pattern of antibody response to desoxyribonuclease has been compared to that of streptokinase and streptolysin O in a group of ninety patients from an epidemic of scarlet fever.
针对部分纯化的链球菌脱氧核糖核酸酶的兔抗血清可抑制该酶对其底物的作用。胰腺脱氧核糖核酸酶的活性不受这些抗血清的影响。同样,针对胰腺核酸酶的抗体也不抑制链球菌酶。某些患者在链球菌感染后会产生针对链球菌脱氧核糖核酸酶的抑制性抗体,偶尔效价会非常高,尽管出现抗体反应的患者比例似乎低于链球菌激酶和链球菌溶血素O的情况。在一组来自猩红热流行区的90名患者中,已将对脱氧核糖核酸酶的抗体反应模式与链球菌激酶和链球菌溶血素O的反应模式进行了比较。