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用血凝法测定人血清中抗A群链球菌多糖抗体

THE DETERMINATION OF ANTIBODY TO GROUP A STREPTOCOCCAL POLYSACCHARIDE IN HUMAN SERA BY HEMAGGLUTINATION.

作者信息

SCHMIDT W C, MOORE D J

出版信息

J Exp Med. 1965 May 1;121(5):793-806. doi: 10.1084/jem.121.5.793.

DOI:10.1084/jem.121.5.793
PMID:14280441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138003/
Abstract

A hemagglutination method employing tanned human O erythrocytes sensitized with purified Group A streptococcal polysaccharide has been developed to measure A polysaccharide antibody in antistreptococcal rabbit and human sera. The reaction of sensitized RBC with known Group A streptococcal rabbit antisera, inhibition of hemagglutination with A polysaccharide, and abolition of hemagglutination and hemagglutination-inhibition by exposure of polysaccharide antigen to A enzyme, which destroys the specific immunologic determinant of A carbohydrate, were utilized to demonstrate the specificity of this hemagglutinating system. The results of A polysaccharide antibody determinations on sera from normal persons, patients convalescent from streptococcal infection, and patients with non-suppurative streptococcal sequelae are presented.

摘要

已开发出一种血凝方法，该方法采用经纯化的A组链球菌多糖致敏的鞣酸处理人O型红细胞，以测定抗链球菌兔血清和人血清中的A多糖抗体。利用致敏红细胞与已知A组链球菌兔抗血清的反应、A多糖对血凝的抑制作用，以及通过将多糖抗原暴露于A酶（该酶可破坏A碳水化合物的特异性免疫决定簇）来消除血凝和血凝抑制，来证明该血凝系统的特异性。文中给出了对正常人、链球菌感染康复患者以及非化脓性链球菌后遗症患者血清中A多糖抗体的测定结果。

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本文引用的文献

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THE ANTIGENIC COMPLEX OF STREPTOCOCCUS HAEMOLYTICUS : III. CHEMICAL AND IMMUNOLOGICAL PROPERTIES OF THE SPECIES-SPECIFIC SUBSTANCE.链球菌抗原复合物：III. 种特异性物质的化学和免疫学特性。
J Exp Med. 1928 Feb 29;47(3):481-91. doi: 10.1084/jem.47.3.481.
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Bacteriologic and immunologic studies on patients with hemolytic streptococcic infections as related to rheumatic fever.溶血性链球菌感染患者与风湿热相关的细菌学和免疫学研究。
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Group A streptococcus polysaccharide: studies on its preparation, chemical composition, and cellular localization after intravenous injection into mice.A组链球菌多糖：关于其制备、化学成分以及静脉注射到小鼠体内后的细胞定位研究。
J Exp Med. 1952 Jan;95(1):105-18. doi: 10.1084/jem.95.1.105.
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5
THE CELLULAR ANTIGENS OF GROUP A STREPTOCOCCI; IMMUNOELECTROPHORETIC STUDIES OF THE C, M, T, PGP, E4, F, AND E ANTIGENS OF SEROTYPE 17 STREPTOCOCCI.A 群链球菌的细胞抗原；17 型链球菌 C、M、T、PGP、E4、F 和 E 抗原的免疫电泳研究
J Exp Med. 1963 Oct 1;118(4):527-56. doi: 10.1084/jem.118.4.527.
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Studies on L forms and protoplasts of group A streptococci. II. Chemical and immunological properties of the cell membrane.A组链球菌L型和原生质体的研究。II. 细胞膜的化学和免疫学特性。
J Exp Med. 1963 Mar 1;117(3):377-99. doi: 10.1084/jem.117.3.377.
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Antibody titers in acute rheumatic fever.急性风湿热中的抗体滴度。
Circulation. 1960 Apr;21:598-614. doi: 10.1161/01.cir.21.4.598.
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Studies on the chemical structure of the streptococcal cell wall. I. The identification of a mucopeptide in the cell walls of groups A and A-variant streptococci.链球菌细胞壁化学结构的研究。I. A组和A变异组链球菌细胞壁中一种粘肽的鉴定。
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9
Further studies on the chemical basis for serological specificity of Group A streptococcal carbohydrate.A组链球菌碳水化合物血清学特异性化学基础的进一步研究。
J Exp Med. 1958 Sep 1;108(3):311-23. doi: 10.1084/jem.108.3.311.
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Variation in the group-specific carbohydrate of group A streptococci. II. Studies on the chemical basis for serological specificity of the carbohydrates.A组链球菌群特异性碳水化合物的变异。II. 碳水化合物血清学特异性的化学基础研究。
J Exp Med. 1956 Nov 1;104(5):629-43. doi: 10.1084/jem.104.5.629.