Bonavina L, Nosadini A, Bardini R, Baessato M, Peracchia A
First Department of Surgery, University of Padua, Medical School, Italy.
Arch Surg. 1992 Feb;127(2):222-6; discussion 227. doi: 10.1001/archsurg.1992.01420020112016.
From 1976 to 1989, 206 patients referred for primary treatment of esophageal achalasia underwent transabdominal Heller's myotomy and anterior fundoplication according to the Dor technique. In the majority of the patients, the cardia was not mobilized, and the myotomy was extended in length for about 10 cm (8 cm on the esophagus and 2 cm on the stomach). There was no operative mortality. Two patients (0.9%) required reoperation due to bleeding from the myotomy site in one and leakage from the gastrotomy site in the other. One hundred ninety-three patients entered the follow-up study and were followed up from 12 to 144 months (median, 64.5 months). Five patients died during the follow-up of unrelated diseases, and in one patient, an esophageal cancer infiltrating the trachea was discovered 26 months after the operation. Clinical results were excellent or good in 93.8% of the patients, and fair in 2.6%. Disabling dysphagia recurred in seven patients (3.6%), six of whom required pneumatic dilation for relief and one patient who underwent reoperation because of a paraesophageal hiatal hernia. Postoperative roentgenographic studies showed a significant reduction in the mean value of the maximal esophageal diameter. Esophageal manometry showed a significant reduction of lower esophageal sphincter pressure and length over preoperative values. Twenty-four-hour esophageal pH monitoring showed an abnormal acid exposure in seven (8.6%) of 81 patients tested. Of these patients, one had erosive esophagitis on endoscopy. Esophageal transit scintigraphy, performed in 11 patients, showed a significant improvement of transit time in the erect position compared with preoperative values. We concluded that transabdominal esophagomyotomy combined with Dor fundoplication is a safe, effective, and durable procedure in the treatment of esophageal achalasia.
1976年至1989年期间,206例因原发性食管贲门失弛缓症而接受治疗的患者,按照Dor技术接受了经腹Heller肌切开术和前胃底折叠术。大多数患者未游离贲门,肌切开术的长度延长约10厘米(食管段8厘米,胃段2厘米)。无手术死亡病例。两名患者(0.9%)因肌切开部位出血(1例)和胃切开部位渗漏(另1例)需要再次手术。193例患者进入随访研究,随访时间为12至144个月(中位数为64.5个月)。5例患者在随访期间死于无关疾病,1例患者在术后26个月发现食管癌侵犯气管。93.8%的患者临床结果为优或良,2.6%为中等。7例患者(3.6%)再次出现致残性吞咽困难,其中6例需要气囊扩张缓解症状,1例因食管旁裂孔疝接受再次手术。术后X线检查显示食管最大直径的平均值显著降低。食管测压显示食管下括约肌压力和长度较术前值显著降低。81例接受24小时食管pH监测的患者中,7例(8.6%)出现异常酸暴露。这些患者中,1例在内镜检查时发现有糜烂性食管炎。11例患者进行了食管通过闪烁扫描,结果显示与术前值相比,直立位时通过时间有显著改善。我们得出结论,经腹食管肌切开术联合Dor胃底折叠术是治疗食管贲门失弛缓症的一种安全、有效且持久的方法。