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沙眼衣原体肺炎可在体内诱导白细胞介素-1和白细胞介素-6的产生。

Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6.

作者信息

Magee D M, Smith J G, Bleicker C A, Carter C J, Bonewald L F, Schachter J, Williams D M

机构信息

Department of Research Immunology, San Antonio State Chest Hospital, Texas 78223.

出版信息

Infect Immun. 1992 Mar;60(3):1217-20. doi: 10.1128/iai.60.3.1217-1220.1992.

DOI:10.1128/iai.60.3.1217-1220.1992
PMID:1541536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC257615/
Abstract

Cytokine induction during Chlamydia trachomatis pneumonia may alter the pathogenesis or course of disease. We examined interleukin-1 (IL-1) and IL-6 production by measuring mRNA and bioactivity in murine lungs. mRNA and bioactivity for IL-1 alpha, IL-1 beta, and IL-6 increased after Chlamydia infection. These cytokines may be important in regulating host defenses against C. trachomatis.

摘要

沙眼衣原体肺炎期间的细胞因子诱导可能会改变疾病的发病机制或病程。我们通过测量小鼠肺中的mRNA和生物活性来检测白细胞介素-1（IL-1）和IL-6的产生。沙眼衣原体感染后，IL-1α、IL-1β和IL-6的mRNA及生物活性增加。这些细胞因子在调节宿主对沙眼衣原体的防御中可能很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7e/257615/8a42a5892232/iai00027-0510-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7e/257615/8a42a5892232/iai00027-0510-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f7e/257615/8a42a5892232/iai00027-0510-a.jpg

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本文引用的文献

1
Development of chronic conjunctivitis with scarring and pannus, resembling trachoma, in guinea-pigs.豚鼠身上出现类似沙眼的伴有瘢痕形成和血管翳的慢性结膜炎。
Br J Ophthalmol. 1980 Apr;64(4):284-90. doi: 10.1136/bjo.64.4.284.
2
Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse.免疫功能低下（裸）小鼠的沙眼衣原体肺炎
J Infect Dis. 1981 Feb;143(2):238-41. doi: 10.1093/infdis/143.2.238.
3
Cellular immunity to the mouse pneumonitis agent.
J Infect Dis. 1984 Apr;149(4):630-9. doi: 10.1093/infdis/149.4.630.
男性无症状衣原体感染患者的精液中白细胞介素-10、白细胞介素-12 和白细胞介素-17 的水平。
Inflammation. 2014 Feb;37(1):122-6. doi: 10.1007/s10753-013-9719-7.
4
T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.T淋巴细胞免疫在宿主抵御沙眼衣原体中的作用及其对疫苗研发的意义。
Can J Infect Dis. 1998 Mar;9(2):99-108. doi: 10.1155/1998/395297.
5
Clinical consequences of immune responses to Chlamydia in men.男性对衣原体免疫反应的临床后果。
Infect Dis Obstet Gynecol. 1996;4(3):136-42. doi: 10.1155/S1064744996000300.
6
The extracellular signal-regulated kinase/mitogen-activated protein kinase pathway induces the inflammatory factor interleukin-8 following Chlamydia trachomatis infection.沙眼衣原体感染后，细胞外信号调节激酶/丝裂原活化蛋白激酶途径可诱导炎性因子白细胞介素-8的产生。
Infect Immun. 2007 Dec;75(12):5924-9. doi: 10.1128/IAI.01029-07. Epub 2007 Sep 24.
7
Binding of LFA-1 (CD11a) to intercellular adhesion molecule 3 (ICAM-3; CD50) and ICAM-2 (CD102) triggers transmigration of human immunodeficiency virus type 1-infected monocytes through mucosal epithelial cells.淋巴细胞功能相关抗原-1（LFA-1，CD11a）与细胞间黏附分子3（ICAM-3，CD50）及细胞间黏附分子2（ICAM-2，CD102）的结合可触发1型人类免疫缺陷病毒感染的单核细胞通过黏膜上皮细胞进行迁移。
J Virol. 2002 Jan;76(1):32-40. doi: 10.1128/jvi.76.1.32-40.2002.
8
Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection.白细胞介素-12和γ干扰素在小鼠肺炎衣原体感染中的作用。
Infect Immun. 2000 Apr;68(4):2245-53. doi: 10.1128/IAI.68.4.2245-2253.2000.
9
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Infect Immun. 2000 Apr;68(4):2237-44. doi: 10.1128/IAI.68.4.2237-2244.2000.
10
Expression of gelatinase B in trachomatous conjunctivitis.沙眼性结膜炎中明胶酶B的表达
Br J Ophthalmol. 2000 Jan;84(1):85-91. doi: 10.1136/bjo.84.1.85.
4
Immunopathology and histopathology of experimental chlamydial salpingitis.实验性衣原体性输卵管炎的免疫病理学与组织病理学
Rev Infect Dis. 1985 Nov-Dec;7(6):746-53. doi: 10.1093/clinids/7.6.746.
5
Pathogenesis and immunology of chlamydial infections of the genital tract.生殖道衣原体感染的发病机制与免疫学
Rev Infect Dis. 1985 Nov-Dec;7(6):741-5. doi: 10.1093/clinids/7.6.741.
6
Importance of reinfection in the pathogenesis of trachoma.再感染在沙眼发病机制中的重要性。
Rev Infect Dis. 1985 Nov-Dec;7(6):717-25. doi: 10.1093/clinids/7.6.717.
7
Distal tubal obstruction induced by repeated Chlamydia trachomatis salpingeal infections in pig-tailed macaques.猪尾猕猴反复感染沙眼衣原体引起的输卵管远端梗阻。
J Infect Dis. 1987 Jun;155(6):1292-9. doi: 10.1093/infdis/155.6.1292.
8
Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-1a.重组人白细胞介素-1α诱导小鼠对细菌感染的抵抗力增强。
Infect Immun. 1987 Jun;55(6):1436-40. doi: 10.1128/iai.55.6.1436-1440.1987.
9
Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.其他细胞因子对人成纤维细胞中干扰素-β2/B细胞分化因子BSF-2/肝细胞刺激因子基因的转录调控
J Immunol. 1988 Feb 1;140(3):974-7.
10
Developmental regulation of the cysteine-rich outer-membrane proteins of murine Chlamydia trachomatis.
J Gen Microbiol. 1988 Apr;134(4):997-1004. doi: 10.1099/00221287-134-4-997.