沙眼衣原体肺炎可在体内诱导白细胞介素-1和白细胞介素-6的产生。
Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6.
作者信息
Magee D M, Smith J G, Bleicker C A, Carter C J, Bonewald L F, Schachter J, Williams D M
机构信息
Department of Research Immunology, San Antonio State Chest Hospital, Texas 78223.
出版信息
Infect Immun. 1992 Mar;60(3):1217-20. doi: 10.1128/iai.60.3.1217-1220.1992.
Cytokine induction during Chlamydia trachomatis pneumonia may alter the pathogenesis or course of disease. We examined interleukin-1 (IL-1) and IL-6 production by measuring mRNA and bioactivity in murine lungs. mRNA and bioactivity for IL-1 alpha, IL-1 beta, and IL-6 increased after Chlamydia infection. These cytokines may be important in regulating host defenses against C. trachomatis.
沙眼衣原体肺炎期间的细胞因子诱导可能会改变疾病的发病机制或病程。我们通过测量小鼠肺中的mRNA和生物活性来检测白细胞介素-1（IL-1）和IL-6的产生。沙眼衣原体感染后，IL-1α、IL-1β和IL-6的mRNA及生物活性增加。这些细胞因子在调节宿主对沙眼衣原体的防御中可能很重要。
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