白细胞介素-6在宿主抵御小鼠沙眼衣原体感染中的作用。
A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection.
作者信息
Williams D M, Grubbs B G, Darville T, Kelly K, Rank R G
机构信息
Division of Infectious Diseases, Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas 78284, USA. dwight.williams@med
出版信息
Infect Immun. 1998 Sep;66(9):4564-7. doi: 10.1128/IAI.66.9.4564-4567.1998.
Abstract
Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.
摘要
与B6129F2/J对照相比，白细胞介素-6缺陷（IL-6(-/-)）基因敲除小鼠在鼻内感染后早期，肺组织中的沙眼衣原体水平显著升高，死亡率也更高。γ干扰素的产生和衣原体特异性抗体水平与IL-6(-/-)小鼠中降低但可逆的Th1样反应一致。最佳的早期宿主对这种感染的反应需要IL-6。
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