Johnson A P
Rev Infect Dis. 1985 Nov-Dec;7(6):741-5. doi: 10.1093/clinids/7.6.741.
In recent years there has been a steady increase in our understanding of the pathogenesis and immunobiology of lower genital tract infections caused by Chlamydia trachomatis. Much of this increase in knowledge has stemmed from two areas of research: clinical, pathologic, and immunologic observations of patients and the development and study of animal models. Research on patients has included the use of techniques such as histologic examination of biopsy specimens and measurement of levels of antibody and/or leukocyte responses to chlamydial antigens. The animal models that have been developed include experimental genital tract infections not only with C. trachomatis but also with appropriate Chlamydia psittaci organisms, such as the agent of guinea pig inclusion conjunctivitis. Continued investigation of the pathophysiologic and immunologic bases of chlamydial genital tract disease should lead to the rational development of potential control measures, such as vaccines or other forms of prophylaxis or therapy.
近年来，我们对沙眼衣原体引起的下生殖道感染的发病机制和免疫生物学的认识稳步增加。知识的这种增加很大程度上源于两个研究领域：对患者的临床、病理和免疫学观察以及动物模型的开发和研究。对患者的研究包括使用活检标本的组织学检查以及测量抗体水平和/或对衣原体抗原的白细胞反应等技术。已开发的动物模型包括不仅用沙眼衣原体而且用适当的鹦鹉热衣原体生物进行的实验性生殖道感染，例如豚鼠包涵体结膜炎病原体。对衣原体生殖道疾病的病理生理和免疫基础的持续研究应能合理开发潜在的控制措施，如疫苗或其他形式的预防或治疗。
