Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China.
Nanyue Biopharmaceutical Co. Ltd., Hunan Province Innovative Training Base for Postgraduates, University of South China and Nanyue Biopharmaceutical Co. Ltd., Hengyang, China.
Front Immunol. 2021 May 21;12:639834. doi: 10.3389/fimmu.2021.639834. eCollection 2021.
Chlamydial infection causes a number of clinically relevant diseases and induces significant morbidity in humans. Immune and inflammatory responses contribute to both the clearance of infection and pathology in host tissues. infection stimulates host cells to produce a large number of cytokines that trigger and regulate host immune responses against . However, inappropriate responses can occur with excessive production of cytokines, resulting in overreactive inflammatory responses and alterations in host or metabolism. As a result, persists and causes wound healing delays, leading to more severe tissue damage and triggering long-lasting fibrotic sequelae. Here, we summarize the roles of cytokines in infection and pathogenesis, thus advancing our understanding chlamydial infection biology and the pathogenic mechanisms involved.
衣原体感染可引起多种临床相关疾病，并导致人类出现显著的发病率。免疫和炎症反应既有助于清除感染，也与宿主组织的病理学改变有关。衣原体感染可刺激宿主细胞产生大量细胞因子，从而触发和调节宿主对衣原体的免疫反应。然而，过度产生细胞因子也可能导致反应不当，引发过度的炎症反应，并改变宿主或衣原体代谢。因此，衣原体持续存在并导致伤口愈合延迟，导致更严重的组织损伤，并引发持久的纤维化后遗症。在这里，我们总结了细胞因子在衣原体感染和发病机制中的作用，从而增进我们对衣原体感染生物学和相关致病机制的理解。
