Keck P E, McElroy S L, Friedman L M
Biological Psychiatry Program, University of Cincinnati College of Medicine, Ohio 45267-0559.
J Clin Psychopharmacol. 1992 Feb;12(1 Suppl):36S-41S. doi: 10.1097/00004714-199202001-00006.
A number of preclinical studies and preliminary clinical reports, in some cases augmented by controlled studies, suggest that valproate and carbamazepine may have therapeutic effects in the treatment of certain anxiety disorders (panic disorder, post-traumatic stress disorder), alcohol and sedative-hypnotic withdrawal states, and behavioral dyscontrol syndromes. We review the theoretical rationale and available clinical data supporting the potential value of these anticonvulsants in these psychiatric disorders.
一些临床前研究和初步临床报告，在某些情况下还辅以对照研究，表明丙戊酸盐和卡马西平在治疗某些焦虑症（惊恐障碍、创伤后应激障碍）、酒精和镇静催眠药戒断状态以及行为失控综合征方面可能具有治疗作用。我们回顾了支持这些抗惊厥药在这些精神疾病中潜在价值的理论依据和现有临床数据。
