Markus H S, Hopkinson N
Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham, UK.
J Neurol. 1992 Jan;239(1):39-42. doi: 10.1007/BF00839210.
It has been reported that migraine is common in systemic lupus erythematous (SLE) and an association with phospholipid antibodies has been suggested. The incidence of migraine and non-migrainous headache was prospectively studied in 90 patients with SLE and 90 age- and sex-matched controls. A history of migraine was commoner in SLE patients than in controls [31(34%) vs 15(16%); P less than 0.05], and the mean age of onset was higher in the SLE group (26.8 vs 17.2 years). Within the SLE group an association was found between migraine and SLE disease activity. Non-migrainous headaches were also more common (non-significant) in the SLE group, and there was a close temporal relationship between onset of both headache and SLE in many patients. Both migraine and non-migrainous headaches in SLE patients often responded to specific SLE treatment. No association was found between migraine or other headaches and antibodies to phospholipids.
据报道，偏头痛在系统性红斑狼疮（SLE）中很常见，并且有人提出它与磷脂抗体有关。我们对90例SLE患者和90例年龄及性别匹配的对照者进行了前瞻性研究，以探讨偏头痛和非偏头痛性头痛的发生率。SLE患者中有偏头痛病史的比对照组更常见[31例（34%）对15例（16%）；P<0.05]，且SLE组的平均发病年龄更高（26.8岁对17.2岁）。在SLE组中，发现偏头痛与SLE疾病活动之间存在关联。非偏头痛性头痛在SLE组中也更常见（无统计学意义），并且在许多患者中，头痛发作与SLE发作之间存在密切的时间关系。SLE患者的偏头痛和非偏头痛性头痛通常对特定的SLE治疗有反应。未发现偏头痛或其他头痛与磷脂抗体之间存在关联。
