Fykse E M, Iversen E G, Fonnum F
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller.
Neurosci Lett. 1992 Jan 20;135(1):125-8. doi: 10.1016/0304-3940(92)90151-v.
The effects of different agents similar in structure to glutamate were tested for inhibition of the vesicular uptake of L-glutamate. Kainate and L-homocysteate turned out to be non-competitive inhibitors of the L-glutamate uptake. Kainate was not taken up by the vesicle fraction. The vesicular uptake of gamma-aminobutyric acid (GABA) was also inhibited by kainate and L-homocysteate. Kynurenate, on the other hand, strongly inhibited the uptake of L-glutamate, whereas the uptake of GABA was hardly affected. L-alpha-Aminoadipate and D-glutamate inhibited the uptake of L-glutamate, whereas L- and D-aspartate and L-cysteate only weakly inhibited the uptake of L-glutamate. GABA, glycine, L-serine and taurine did not inhibit the uptake of L-glutamate.
测试了结构与谷氨酸相似的不同试剂对L-谷氨酸囊泡摄取的抑制作用。结果表明，海人酸和L-高半胱氨酸是L-谷氨酸摄取的非竞争性抑制剂。海人酸不被囊泡部分摄取。γ-氨基丁酸（GABA）的囊泡摄取也受到海人酸和L-高半胱氨酸的抑制。另一方面，犬尿氨酸强烈抑制L-谷氨酸的摄取，而GABA的摄取几乎不受影响。L-α-氨基己二酸和D-谷氨酸抑制L-谷氨酸的摄取，而L-和D-天冬氨酸以及L-半胱氨酸仅微弱抑制L-谷氨酸的摄取。GABA、甘氨酸、L-丝氨酸和牛磺酸不抑制L-谷氨酸的摄取。
