大鼠腹腔注射或脑室内注射苯环利定后辨别刺激特性的比较。

A comparison of the discriminative stimulus properties of phencyclidine, given intraperitoneally or intraventricularly in rats.

作者信息

Slifer B L, Balster R L

出版信息

Neuropharmacology. 1985 Dec;24(12):1175-9. doi: 10.1016/0028-3908(85)90151-0.

Abstract

Rats trained to discriminate intraperitoneally injected phencyclidine (PCP) from saline in a two-lever operant procedure distributed most of their responses on the phencyclidine lever after administration of 150 or 300 micrograms of phencyclidine into a lateral ventricle. This demonstrated that the discriminative stimulus properties of phencyclidine were centrally mediated. On the other hand, the potency of phencyclidine was increased by no more than about 7-fold from intraperitoneal to intraventricular administration. This suggests that either periventricular sites are not involved in mediating the discriminative stimulus properties of phencyclidine or that absorption of phencyclidine to relevant sites in the brain is not markedly enhanced by intraventricular administration.

摘要

在两杆操作性程序中接受训练以区分腹腔注射苯环利定（PCP）和生理盐水的大鼠，在向侧脑室注射150或300微克苯环利定后，其大部分反应分布在苯环利定杆上。这表明苯环利定的辨别刺激特性是由中枢介导的。另一方面，从腹腔给药到脑室内给药，苯环利定的效力增加不超过约7倍。这表明要么脑室周围部位不参与介导苯环利定的辨别刺激特性，要么脑室内给药不会显著增强苯环利定在大脑相关部位的吸收。