Smallridge R C, Rajfer S, Davia J, Schaaf M
Am J Med. 1979 Jan;66(1):22-7. doi: 10.1016/0002-9343(79)90477-7.
Twenty-seven patients with acromegaly had echocardiograms performed to delineate the ventricular septum, left ventricular posterior wall and mitral valve. Left ventricular function was assessed by calculating the systolic internal dimensional shortening of the left ventricle. Six patients met the criteria for asymmetric septal hypertrophy and eight had concentric left ventricular hypertrophy. The remaining 13 patients were categorized as "normal," although six had septal measurements greater than 11 mm. The group with asymmetric septal hypertrophy had significantly greater percentage of internal dimensional shortening during systole than either the normal group (p less than 0.05) or the group with left ventricular hypertrophy (p less than 0.01). Initial mean growth hormone levels were considerably higher in the group with left ventricular hypertrophy than in the normal group (93 versus 34 ng/ml). Thus, echocardiographic abnormalities are common in acromegaly, and patients with asymmetric septal hypertrophy and acromegaly appear to have significantly increased ventricular ejection. Many of the patients with left ventricular hypertrophy have no evidence of clinical cardiovascular disease, and their left ventricular hypertrophy may be related to higher initial growth hormone levels.
对27例肢端肥大症患者进行了超声心动图检查，以描绘室间隔、左心室后壁和二尖瓣。通过计算左心室收缩期内径缩短率来评估左心室功能。6例符合不对称性室间隔肥厚标准，8例有同心性左心室肥厚。其余13例患者被归类为“正常”，尽管其中6例室间隔测量值大于11mm。不对称性室间隔肥厚组在收缩期内径缩短的百分比显著高于正常组（p<0.05）或左心室肥厚组（p<0.01）。左心室肥厚组的初始平均生长激素水平明显高于正常组（93对34ng/ml）。因此，超声心动图异常在肢端肥大症中很常见，不对称性室间隔肥厚和肢端肥大症患者的心室射血似乎显著增加。许多左心室肥厚患者没有临床心血管疾病的证据，他们的左心室肥厚可能与较高的初始生长激素水平有关。
