Gilbert R, Rudd P, Berry P J, Fleming P J, Hall E, White D G, Oreffo V O, James P, Evans J A
Bath Unit for Research into Paediatrics, London.
Arch Dis Child. 1992 Feb;67(2):171-7. doi: 10.1136/adc.67.2.171.
Three methods were used to investigate the role of infection in sudden unexpected infant death (SUD): (i) microbiological comparison of SUD victims and matched, live, community controls; (ii) postmortem classification of the contribution of infection to death; and (iii) case-control analysis of the relative risk associated with both infection and heavy wrapping. Limited sampling from the upper respiratory tract and gut in SUD victims and controls showed no significant excess of viral infection in the SUD victims (odds ratio = 1.98, 95% confidence interval (CI) 0.9 to 4.5). At postmortem examination, infection explained death in 3/95 babies and may have contributed to death in 37/95. Over 70 days of age, the combined presence of viral infection and wrapping in excess of 10 togs produced an odds ratio of SUD of 51.5 (95% CI 5.64 to 471.48) compared with wrapping of less than 6 togs. Viral infection was not a major risk factor as long as babies were lightly wrapped. In heavily wrapped babies the presence of a viral infection greatly increased the risk of SUD.
采用三种方法来研究感染在婴儿猝死综合征（SUD）中的作用：（i）对SUD受害者与匹配的社区存活对照进行微生物学比较；（ii）对感染对死亡的贡献进行尸检分类；（iii）对与感染和过度包裹相关的相对风险进行病例对照分析。对SUD受害者和对照的上呼吸道和肠道进行有限采样显示，SUD受害者中病毒感染并无显著过量（比值比 = 1.98，95%置信区间（CI）0.9至4.5）。尸检时，感染导致3/95例婴儿死亡，可能导致37/95例婴儿死亡。超过70日龄时，与包裹小于6托格相比，病毒感染与包裹超过10托格同时存在使SUD的比值比达到51.5（95% CI 5.64至471.48）。只要婴儿包裹较轻，病毒感染就不是主要危险因素。在包裹厚重的婴儿中，病毒感染的存在会大大增加SUD的风险。
