Fleming P J, Blair P S, Bacon C, Bensley D, Smith I, Taylor E, Berry J, Golding J, Tripp J
Foundation for the Study of Infant Deaths Research Unit, Royal Hospital for Sick Children, Bristol.
BMJ. 1996 Jul 27;313(7051):191-5. doi: 10.1136/bmj.313.7051.191.
To investigate the role of sleeping arrangements as risk factors for the sudden infant death syndrome after a national risk reduction campaign.
Two year population based case-control study. Parental interviews were conducted for each infant who died and for four controls matched for age and date of interview.
Three regions in England with a total population of 17 million people.
195 babies who died and 780 matched controls.
Prone and side sleeping positions both carried increased risks of death compared with supine when adjusted for maternal age, parity, gestation, birth weight, exposure to smoke, and other relevant factors in the sleeping environment (multivariate odds ratio = 9.00 (95% confidence interval 2.84 to 28.47) and 1.84 (1.02 to 3.31), respectively). The higher incidence of side rather than prone sleeping led to a higher population attributable risk (side 18.4%, prone 14.2%). More of the infants who died were found with bed covers over their heads (21.58; 6.21 to 74.99). The use of a dummy had an apparent protective effect (0.38; 0.21 to 0.70). Bed sharing for the whole night was a significant risk factor for infants whose mothers smoked (9.25; 2.31 to 34.02). No protective effect of breast feeding could be identified on multivariate analysis.
This study confirms the importance of certain risk factors for the sudden infant death syndrome and identifies others-for example, covers over the head, side sleeping position-which may be amenable to change by educating and informing parents and health care professionals.
在全国开展降低风险运动后,调查睡眠安排作为婴儿猝死综合征风险因素的作用。
基于人群的两年病例对照研究。对每例死亡婴儿以及四名年龄和访谈日期匹配的对照婴儿的父母进行访谈。
英格兰的三个地区,总人口为1700万。
195名死亡婴儿和780名匹配的对照婴儿。
在对母亲年龄、产次、孕周、出生体重、接触烟雾及睡眠环境中的其他相关因素进行校正后,俯卧位和侧卧位睡眠与仰卧位相比,死亡风险均增加(多变量优势比分别为9.00(95%置信区间2.84至28.47)和1.84(1.02至3.31))。侧卧位而非俯卧位睡眠的较高发生率导致人群归因风险更高(侧卧位18.4% ,俯卧位14.2%)。更多死亡婴儿被发现头部盖有床单(21.58;6.21至74.99)。使用安抚奶嘴有明显的保护作用(0.38;0.21至0.70)。对于母亲吸烟的婴儿,整夜与母亲同床是一个重要的风险因素(9.25;2.31至34.02)。多变量分析未发现母乳喂养有保护作用。
本研究证实了某些婴儿猝死综合征风险因素的重要性,并确定了其他一些因素——例如,头部盖床单、侧卧位睡眠——通过对父母和医护人员进行教育和宣传,这些因素可能是可以改变的。