Liebold R, Dinjus U, Selbitz H J
Veterinärmedizinische Fakultät, Institut für Mikrobiologie und Tierseuchenlehre, Universität Leipzig.
Berl Munch Tierarztl Wochenschr. 1992 Jan 1;105(1):5-10.
A survey is given on the presence and the detection of entero- and cytotoxin production of Salmonella. Their role in the pathogenesis of Salmonellosis has not yet been clarified completely. The standardization of the terms of toxins according place and modus of action is proposed. Cytotonic and cytotoxic enterotoxins were demonstrated in Salmonella strains. Toxins, like the Verotoxin of E. coli, acting in enterocytes as well as in other cells of organisms have not been detected in Salmonella strains. For detection cell culture assays are preferred, DNA-hybridization will be of importance in the near future.
本文对沙门氏菌产生肠毒素和细胞毒素的情况及检测方法进行了综述。它们在沙门氏菌病发病机制中的作用尚未完全阐明。建议根据毒素的作用部位和作用方式对毒素术语进行标准化。在沙门氏菌菌株中已证实存在细胞张力性和细胞毒性肠毒素。在沙门氏菌菌株中未检测到像大肠杆菌维罗毒素那样作用于肠上皮细胞以及生物体其他细胞的毒素。对于检测,细胞培养测定法是首选方法,DNA杂交在不久的将来将具有重要意义。