大鼠腺胃和胰腺中I组磷脂酶A2 mRNA的表达。个体发育及醋酸可的松的影响。

Group I phospholipase A2 mRNA expression in rat glandular stomach and pancreas. Ontogenic development and effects of cortisone acetate.

作者信息

Dimberg J, Gustafson-Svärd C, Weström B, Tagesson C, Söderkvist P

机构信息

Clinical Research Center, Faculty of Health Sciences, Linköping University, Sweden.

出版信息

Biochim Biophys Acta. 1992 Feb 28;1130(1):47-51. doi: 10.1016/0167-4781(92)90460-h.

DOI:10.1016/0167-4781(92)90460-h

PMID:1543748

Abstract

The postnatal development of group I phospholipase A2 (group I PLA2) in the glandular stomach and pancreas of neonatal rats was investigated. The amounts of group I PLA2 mRNA (and also the PLA2 enzymatic activity) in the glandular stomach mucosa increased with age in 3-60-day-old animals. This postnatal development of rat stomach group I PLA2 mRNA agreed with that of group I PLA2 mRNA of the rat pancreas, and thus seems to follow the general development of the gastrointestinal tract during the neonatal period. The latter was further supported by the finding that maturation of group I PLA2 in both the stomach and pancreas was induced precociously in rats treated with cortisone acetate. It is suggested that the stomach group I PLA2 is involved in mucosal eicosanoid production.

摘要

研究了新生大鼠腺胃和胰腺中I型磷脂酶A2（I型PLA2）的出生后发育情况。在3至60日龄的动物中，腺胃黏膜中I型PLA2 mRNA的量（以及PLA2酶活性）随年龄增长而增加。大鼠胃I型PLA2 mRNA的这种出生后发育情况与大鼠胰腺I型PLA2 mRNA的发育情况一致，因此似乎遵循新生儿期胃肠道的总体发育情况。醋酸可的松处理的大鼠胃和胰腺中I型PLA2早熟成熟这一发现进一步支持了上述观点。提示胃I型PLA2参与黏膜类花生酸的产生。