大鼠胃黏膜和肺中胰腺型磷脂酶A2信使核糖核酸的存在
Presence of pancreatic-type phospholipase A2 mRNA in rat gastric mucosa and lung.
作者信息
Sakata T, Nakamura E, Tsuruta Y, Tamaki M, Teraoka H, Tojo H, Ono T, Okamoto M
机构信息
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
出版信息
Biochim Biophys Acta. 1989 Jan 23;1007(1):124-6. doi: 10.1016/0167-4781(89)90141-3.
The content of mRNA for a pancreatic-type phospholipase A2 present in rat gastric mucosa was much greater than that in pancreas. In lung the mRNA for this pancreatic-type phospholipase A2 was also detected, but less than in pancreas. Nucleotide sequence analysis showed that these pancreatic-type phospholipase A2 cDNAs derived from rat gastric mucosa and lung were completely identical to that from rat pancreas (Ohara et al. (1986) J. Biochem. 99, 733-739). This demonstrates that the pancreatic-type phospholipase A2 present in gastric mucosa and lung does not originate from pancreas.
大鼠胃黏膜中存在的胰腺型磷脂酶A2的mRNA含量远高于胰腺中的含量。在肺中也检测到了这种胰腺型磷脂酶A2的mRNA，但含量低于胰腺。核苷酸序列分析表明，源自大鼠胃黏膜和肺的这些胰腺型磷脂酶A2的cDNA与源自大鼠胰腺的cDNA完全相同（Ohara等人，（1986年）《生物化学杂志》99卷，733 - 739页）。这表明胃黏膜和肺中存在的胰腺型磷脂酶A2并非源自胰腺。
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